Association between sHLA-G and HLA-G 14-bp deletion/insertion polymorphism in Crohn’s disease
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چکیده
منابع مشابه
Association between HLA-G 14-bp insertion/deletion polymorphism and cancer risk: a meta-analysis.
PURPOSE A number of studies have investigated the association between human leukocyte antigen-G (HLA-G) 14-bp insertion/deletion polymorphism and cancer risk, but the results remain controversial. In this study we aimed to clarify whether this association really exists. METHODS We carried out a meta-analysis of 8 studies including 1179 cases and 2795 controls from PubMed and Chinese language ...
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The non-classical class I human leukocyte antigen (HLA)-G molecule was found to be predominately expressed in the extravillous cytotrophoblasts at the fetal-maternal interface during pregnancy. This molecule is critically important for successful implantation during human pregnancy. The polymorphic insertion-deletion (indel) 14-base pair (bp) site localized at the 3' untranslated region was ass...
متن کاملthe hla-g 14-bp insertion/ deletion polymorphism in recurrent spontaneous abortion among iranian women
hla-g is a non-classical hla class ib molecule with limited protein variability generated by alternative splicing. hla-g displays immunotolerant properties and hence plays important roles in the maintenance of a successful pregnancy and maternal tolerance of the semiallogenic fetus. polymorphism of the hla-g gene may potentially affect the biological properties of the protein, and a ...
متن کاملAntigens HLA-G, sHLA- G and sHLA- class I in reproductive failure.
It can be supposed that relation between HLA-G polymorphism and sHLA-G protein expression are associated with successful embryo implantation and pregnancy maintenance. The aim of the study was the estimation specific differences in expression of sHLA-G and sHLA- class I antigens in women with reproductive failure in comparison with fertile women. The study sample enrolled 80 women, divided into...
متن کاملRelationship between the HLA-G 14 bp insertion/deletion polymorphism and susceptibility to autoimmune disease: a meta-analysis.
Numerous studies have investigated the potential relationship between the human leukocyte antigen (HLA)-G 14-bp insertion/deletion (INS/DEL) polymorphisms and autoimmune disease (AID). However, published results are inconclusive. Our aim was to determine whether the 14-bp INS/DEL polymorphism in the HLA-G gene contributes to the risk of AID. A systemic literature search of the PubMed and EMBASE...
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ژورنال
عنوان ژورنال: International Immunology
سال: 2015
ISSN: 1460-2377,0953-8178
DOI: 10.1093/intimm/dxv002